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Overview
Here’s the complete overview of Fundamentals of Modern Bioprocessing 1st Edition PDF:
Biological drug and vaccine manufacturing has quickly become one of the highest-value fields of bioprocess engineering, and many bioprocess engineers are now finding job opportunities that have traditionally gone to chemical engineers. Fundamentals of Modern Bioprocessing addresses this growing demand.
Written by experts well-established in the field, this book connects the principles and applications of bioprocessing engineering to healthcare product manufacturing and expands on areas of opportunity for qualified bioprocess engineers and students. The book is divided into two sections: the first half centers on the engineering fundamentals of bioprocessing; while the second half serves as a handbook offering advice and practical applications.
Focused on the fundamental principles at the core of this discipline, this work outlines every facet of design, component selection, and regulatory concerns. It discusses the purpose of bioprocessing (to produce products suitable for human use), describes the manufacturing technologies related to bioprocessing, and explores the rapid expansion of bioprocess engineering applications relevant to health care product manufacturing. It also considers the future of bioprocessing―the use of disposable components (which is the fastest growing area in the field of bioprocessing) to replace traditional stainless steel.
Features of Fundamentals of Modern Bioprocessing 1st Edition PDF
Here’s a quick overview of the important features of this book:
- Discusses the many types of genetically modified organisms
- Outlines laboratory techniques
- Includes the most recent developments
- Serves as a reference and contains an extensive bibliography
- Emphasizes biological manufacturing using recombinant processing, which begins with creating a genetically modified organism using recombinant techniques
Table of Contents
Below is the complete table of contents offered inside Fundamentals of Modern Bioprocessing 1st Edition PDF:
ENGINEERING FUNDAMENTALS OF BIOPROCESSING
Frontiers of Bioprocessing
- Defining Bioprocessing
- Current and Emerging Trends in Bioprocess Engineering
- Materials Advances
- Nanoscale Advances
- Bioprocessing for Chemical and Biologic Product Manufacturing
- Bioprocessing Leaders Worldwide
- Economic Predictions and Careers in Bioprocess Engineering
- Skills Needed for Future Bioprocess Engineers
- Appendix A: A Time Line of Biotechnology Development
Introduction to Molecular Biology
- Introduction
- Building Blocks of Life: DNA, RNA, and Proteins
- DNA Replication
- Transcription
- Translation
- Genes
- Mutations
- Chromosome
- DNA Cloning
Introduction to Biochemistry
- Introduction
- DNA Structure
- RNA Structure
- Protein Structure and Function
- Carbohydrates
- Lipids, Fats, and Steroids
- Basic Metabolic Pathways
Introduction to Cellular Microbiology
- Introduction
- General Cell Structure
- Eukaryotes, Prokaryotes, Archaea, and Viruses
- Intracellular Organelles
- Cellular Transport
- Intracellular Signal Transduction
Reaction Stoichiometry, Thermodynamics, and Kinetics
- Introduction
- Mass and Energy Balances
- Fundamentals of Chemical Reactions
- Basic Mass Transfer: Diffusion and Convection
- Basic Fluid Dynamics
- Basic Thermodynamics
- Basic Reaction Kinetics
Kinetics of Enzymes and Cell Growth
- Introduction
- Basic Michaelis–Menten Kinetics
- Michaelis–Menten Kinetics with Inhibition
- pH and Transport Limitations
- Other Enzyme Kinetics
- Prokaryotic and Eukaryotic Growth Models
- Advanced Prokaryotic and Eukaryotic Growth Models
Data Management
- Introduction
- Good Laboratory Practices
- Electronic Data Handling
- Data Errors
- Statistical Analysis
- Data Conclusions
- Flow Diagrams
- Exercises and Solutions
Elements of Bioprocessing
- Introduction
- Upstream Processing
- Bioreactor
- Downstream Processing
Genetically Modified Organisms
- Introduction
- Cell Line Characterization
- Characterization of Cell and Virus Banks
- Cell Line Construction
- Designing GMCS
- Vector
- Host Systems
- Expression System in E Coli
- Configuration of Efficient Expression Vectors
- Protein Production
- Genetic Manipulations to Improve Yield
Manufacturing Overview
- Introduction
- Cell Culture Expression Systems
- Transgenic Animals
- Cell Lines and Characterization
- Media
- Culture Growth
- Extraction, Isolation, and Purification
- Capture
- Purification
- Impurity Removal
- Validation
- Intermediate Purification
- Polishing
- Formulation
- Process Overview
- Tech Transfer and Documentation
- Validation
- Scale Up
- Specific Economy Issues
- Process Materials
- Environment Control
- Good Manufacturing Controls of Active Pharmaceutical Ingredients
- Manufacturing Systems and Layout
- Cleaning Procedures
- Processing and Filling
- Laboratory Testing
- Laboratory Controls
- Documentation
- Technical Package
- Outsourcing in Biotech Manufacturing
- Issues to Discuss
Disposable Bioprocessing Systems
- Introduction
- Safety of Disposable Systems
- Regulatory Matters
- Risk Assessment
- Disposable Containers
- Tank Liners
- Mixing Systems
- Disposable Bioreactors
- Disposable Connectors and Transfers
- Disposable Control and Monitoring Systems
- Downstream Processing
- Filtration
Upstream Processing
- Introduction
- Bioreactors
- Batch Culture
- Continuous Culture
- Fed-Batch Culture
- Perfusion Culture
- Suspension Culture
- Microcarrier Support
- Roller Bottle Culture System
- Spinner Flask Culture
- Other Scale up Options
- Wave Bioreactor
- Cell Cube Technology
- Rotary Culture System
- Media
- Scaling and Production Costs
- Problem Resolution in Fusion Protein Expression
Downstream Processing
- Introduction
- Capture
- System Suitability
- Downstream Processing Systems
- Process Flow
Purification
- Introduction
- Protein Properties
- Affinity Chromatography
- Immobilized Metal Affinity Chromatography
- Anion Exchange Chromatography
- Cation Exchange Chromatography
- Size Exclusion Chromatography
- Reversed Phase Chromatography
- Hydroxyapatite Chromatography
- Hydrophobic Interaction Chromatography
- Scale-up and Optimization
Manufacturing Systems
- Bacterial Expression Systems
- Genetically Modified Bacteria
- Mammalian Cells Manufacturing Systems
- Yeast Cell Expression System
- Insect Cells Systems
Quality Consideration
- Introduction
- Management Responsibilities
- Resources
- Manufacturing Operations
- Evaluation Activities
- Conclusion
- QA Systems
- Validation Master Plan
- Raw Materials
- Column Life
- Process
- Virus Validation
- Testing of Product
- In-Process Control
- Regulatory Affairs
- Regulatory Issues
- Protein Degradation
- Stability Considerations
Intellectual Property
- Introduction
- Patenting Systems and Strategies
- The Patent Laws
- Types of Patent Laws
- Anatomy of a Patent
- Patentability
- Patentability and Technical Information Search
- Components of a Patent Application
- Inventions of Interest to Pharmaceutical Scientists
- Biotechnology Inventions
- Patenting Strategies
Product Details
Below are the technical specifications of Fundamentals of Modern Bioprocessing 1st Edition PDF:
- ASIN : 1138893293
- Publisher : CRC Press; 1st edition (July 26, 2017)
- Language : English
- Paperback : 740 pages
- ISBN-10 : 9781138893290
- ISBN-13 : 978-1138893290
- Item Weight : 2.95 pounds
- Dimensions : 7 x 10 inches
Fundamentals of Modern Bioprocessing 1st Edition PDF Free Download
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