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Overview
Here’s the complete overview of Congenital and Acquired Bone Marrow Failure 1st Edition PDF:
Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients.
Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.
Features of Congenital and Acquired Bone Marrow Failure 1st Edition PDF
Here’s a quick overview of the important features of this book:
- Provides an overview of all congenital and acquired bone marrow failure syndromes
Focuses on the molecular pathogenesis, clinical manifestation and diagnosis, laboratory features, and treatment of each disease within the syndromes - Features the area of supportive care which is a topic of great interest to infectious disease physicians and those involved in transfusion services
Mahmoud Deeb Aljurf (Author)
Dr. Mahmoud Aljurf is Professor of Medicine at Alfaisal University and the Director of Adult Stem Cell Transplant Program at King Faisal Specialist Hospital & Research Center in Riyadh, Saudi Arabia.
He received his M.D. degree in 1985. He completed residency training in Internal Medicine at Brigham and Women’s Hospital, Harvard Medical School, and combined Hematology and Oncology Fellowships at Stanford University Medical Center. He also received Masters in Public Health (MPH) form Johns Hopkins University and FRCPath from UK. Dr. Aljurf is American Board Certified in Internal Medicine, Medical Oncology, Hematology, Medical Management and Quality Assurance. Dr. Aljurf has published over 150 scientific papers and several book chapters. He is the Scientific Director of the Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT), also the Editor in Chief for the journal Hematology/Oncology and Stem Cell Therapy. He was a recipient of the American College of Physician (ACP) Mastership Award for the year 2012. The King Faisal Specialist Hospital & Research Center in Riyadh, Saudi Arabia has one of the world’s largest units for treatment and transplantation of bone marrow failure patients.
Table of Contents
Below is the complete table of contents offered inside Congenital and Acquired Bone Marrow Failure 1st Edition PDF:
- List of Contributors
- Introduction
- Chapter 1: Epidemiology of Acquired Bone Marrow Failure
- Abstract
- Introduction
- Incidence of AA in different geographical regions and race
- Age and gender related demographics of AA
- Posthepatitis AA and AA occurring after viral infections
- AA and association with toxins/drugs
- AA and association with HLA genes
- AA and autoimmune disorders
- AA during pregnancy
- AA postvaccination
- Problems with epidemiological studies in AA and future strategies
- Chapter 2: Pathophysiology of Acquired Bone Marrow Failure
- Abstract
- Introduction: Evidence and inferences from the clinic
- Pathophysiology
- Treatments for AA
- Conclusions
- Chapter 3: Diagnosis of Acquired Aplastic Anemia
- Abstract
- Introduction
- Approach to diagnosis of aplastic anemia
- Diagnosis confirmation
- Characterization of aplastic anemia
- Future challenges in the diagnostics of AA
- Acknowledgment
- Chapter 4: Acquired Overlap Bone Marrow Failure Disorders
- Abstract
- Introduction
- Hypoplastic MDS
- Single lineage cytopenias (pure red cell aplasia or immune thrombocytopenia)
- T cell large granular lymphocytes
- Paroxysmal nocturnal hemoglobinuria
- Congenital marrow failure undiagnosed
- Conclusions
- Chapter 5: Supportive Care in Aplastic Anemia
- Abstract
- Introduction
- Prevention of infections by general medical management of aplastic anemia patients
- Prevention of infections by antibiotic/antimycotic/antiviral prophylaxis
- Hematopoietic growth factors as prophylaxis of infections or in combination with immunosuppression to improve quality of response
- Treatment of infections
- Transfusion therapy
- Iron chelation therapy
- Physical exercise
- Gender-specific issues/sex life
- Psychological support
- Chapter 6: Immunosuppressive Therapy for Aplastic Anemia
- Abstract
- The immune defect in aplastic anemia and the rationale for immunosuppressive therapy
- Treatment options and indications for IST
- ATG: possible mechanisms of action and administration
- Historical development of the current standard ATG protocol (horse ATG combined with cyclosporine)
- Alternative strategies used in an attempt to improve response to standard IST with ATG + CSA (Fig. 6.2)
- The use of alemtuzumab in AA
- Treatment of NSAA
- Predictive factors for response to ATG
- Repeat courses of ATG for nonresponse and relapse
- Clonal transformation to MDS/AML after IST
- Future directions
- Chapter 7: Identical Sibling Donor Transplantation
- Abstract
- Introduction
- Indication for identical sibling donor transplantation
- Conditioning regimen
- Syngeneic stem cell transplantation in aplastic anemia
- The source of the stem cells
- Posttransplantation immunosuppression
- Posttransplant care
- Chapter 8: Unrelated Donor Transplants for Acquired Aplastic Anemia
- Abstract
- Eligibility in acquired SAA for UD transplantation
- Upper age limit for UD transplants
- Outcome of patients activating a UD search
- HLA matched or mismatched donors
- Graft rejection and stem cell source
- Cyclophosphamide and the conditioning regimen for UD transplants
- An update of EBMT data on UD transplants
- Alemtuzumab instead of ATG
- Graft versus host disease prophylaxis
- Improvement of UD transplants with time and supportive care
- Conclusions
- Chapter 9: Umbilical Cord Blood Transplantation for Patients With Acquired and Inherited Bone Marrow Failure Syndromes on Behalf of Eurocord
- Abstract
- Introduction
- Candidates for cord blood transplantation for aplastic anemia
- HLA-identical sibling cord blood transplant: Eurocord results
- Unrelated cord blood transplantation for BMFS
- Recommendations for cord blood transplantation in BMF
- Future directions
- Chapter 10: Haploidentical Transplantation
- Abstract
- Ex vivo T-cell depletion
- Unmanipulated graft haplo-SCT
- Conclusions
- Chapter 11: Management of Acquired Aplastic Anemia in Children
- Abstract
- Diagnosis and clinical characteristics
- Supportive treatment
- General concepts for specific treatment
- Options for first-line treatment
- Options for second line treatments
- Options for third line treatments
- Chapter 12: Treatment of Elderly Patients With Aplastic Anemia
- Abstract
- Aging and its consequences on the approach to treatment
- Comprehensive geriatric assessment
- Treatment of aplastic anemia in the elderly
- Open questions in the treatment of elderly patients with aplastic anemia
- Conclusions
- Acknowledgments
- Chapter 13: Emerging New Therapies for Acquired Bone Marrow Failure Disorders
- Abstract
- Introduction
- Alternative strategies of immunosuppression
- Nonimmunosuppressive strategies
- Combination strategies
- Conclusions
- Chapter 14: Bone Marrow Failure in Paroxysmal Nocturnal Hemoglobinuria
- Abstract
- Introduction
- Pathophysiology of BMF in PNH
- PNH clone in patients with BMF
- Treatment
- Conclusions
- Chapter 15: Telomere Biology and Disease
- Abstract
- Introduction
- Molecular biology of telomeres and telomerase
- Genotype and phenotype in telomere disease
- Bone marrow, organ failure, and malignancy in telomeropathies
- Diagnosis of telomere disease
- Conclusions
- Chapter 16: Fanconi Anemia
- Abstract
- Introduction
- Diagnosis and staging
- Hematopoietic stem cell transplantation (HSCT)
- Post-HCT monitoring in FA
- Conclusions
- Chapter 17: Ribosomopathies and the Quality Control of Ribosome Assembly
- Abstract
- Introduction
- Diamond–Blackfan anemia
- Shwachman–Diamond syndrome
- Additional ribosomopathies
- Conclusions
- Acknowledgments
- Chapter 18: Dyskeratosis Congenita
- Abstract
- Background
- Pathobiology
- Clinical features
- Diagnosis
- Management
- Conclusions
- Chapter 19: Amegakaryocytic Thrombocytopenia
- Abstract
- Introduction
- Chapter 20: Severe Congenital Neutropenias and Other Rare Inherited Disorders With Marrow Failure
- Abstract
- Severe congenital neutropenia
- Other rare diseases
- Chapter 21: Bone Marrow Failure Syndromes in Children
- Abstract
- Introduction
- Next generation sequencing for inherited BMFs
- Childhood aplastic anemia and refractory cytopenia of childhood
- The treatment algorithm for severe AA in children
- Index
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Product Details
Below are the technical specifications of Congenital and Acquired Bone Marrow Failure 1st Edition PDF:
- Hardcover:Â 274 pages
- Publisher:Â Elsevier; 1 edition (January 23, 2017)
- Language:Â English
- ISBN-10:Â 0128041528
- ISBN-13:Â 978-0128041529
- Product Dimensions:Â 7.5 x 0.7 x 9.2 inches
- Shipping Weight:Â 1.8 pounds
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